Common VDR polymorphisms and idiopathic short stature in children from northern Greece.
Τίτλος | Common VDR polymorphisms and idiopathic short stature in children from northern Greece. |
Publication Type | Journal Article |
Year of Publication | 2015 |
Authors | Emmanouilidou, E., Galli-Tsinopoulou A., Kyrgios I., Gbandi E., & Goulas A. |
Journal | Hippokratia |
Volume | 19 |
Issue | 1 |
Pagination | 25-9 |
Date Published | 2015 Jan-Mar |
ISSN | 1108-4189 |
Abstract | BACKGROUND: A Vitamin D Receptor gene (VDR) polymorphism, rs10735810 (Fok1), has been associated in the past with idiopathic short stature (ISS) in a linkage study. We have investigated the association of the same, as well as a different polymorphism in the same gene [rs731236 (Taq1)] with ISS, in an independent study in Greek children.METHODS: The VDR rs10735810 (Fok1) and rs731236 (Taq1) polymorphisms were genotyped in a group of ISS children (n= 47) and an age and sex-matched group of normal height children (n= 60) from northern Greece. Genotyping was accomplished through established PCR-RFLP methods.RESULTS: An association trend of rs10735810 with ISS was observed, with the TT (ff) genotype being apparently underrepresented among ISS children compared to controls (p= 0.076; OR= 0.165, 95% CI= 0.025-1.094).CONCLUSIONS: The above results, together with recent evidence related to the functionality of the rs10735810 polymorphism, cannot exclude an involvement of VDR in the pathogenesis of ISS. Hippokratia 2015, 19 (1): 25-29. |
Alternate Journal | Hippokratia |
PubMed ID | 26435642 |
PubMed Central ID | PMC4574581 |