Cumulative High-Grade Squamous Intraepithelial Lesion Rate and Need for Surgical Intervention of Atypical Squamous Cells of Undetermined Significance Cytology-Diagnosed Patients: A Prospective Study.
Τίτλος | Cumulative High-Grade Squamous Intraepithelial Lesion Rate and Need for Surgical Intervention of Atypical Squamous Cells of Undetermined Significance Cytology-Diagnosed Patients: A Prospective Study. |
Publication Type | Journal Article |
Year of Publication | 2017 |
Authors | Petousis, S., Kalogiannidis I., Margioula-Siarkou C., Mamopoulos A., Mavromatidis G., Prapas N., & Rousso D. |
Journal | Gynecol Obstet Invest |
Volume | 82 |
Issue | 3 |
Pagination | 247-251 |
Date Published | 2017 |
ISSN | 1423-002X |
Λέξεις κλειδιά | Adult, Aged, Atypical Squamous Cells of the Cervix, Cervical Intraepithelial Neoplasia, Colposcopy, Female, Humans, Middle Aged, Pregnancy, Prospective Studies, Squamous Intraepithelial Lesions of the Cervix, Uterine Cervical Neoplasms |
Abstract | OBJECTIVE: Τhe study aimed to study the rate of atypical squamous cells of undetermined significance (ASCUS) that progressed to high-grade squamous intraepithelial lesions (HGSIL), as well as the number of patients who finally necessitated a surgical intervention during follow-up.METHODS: A prospective study was conducted on patients admitted for colposcopy during 2007-2012. We exclusively included those who presented with newly ASCUS diagnosis, while patients with a history of cervical intraepithelial neoplasia (CIN) were excluded. Primary end points were the cumulative rate of HGSIL during follow-up and the rate of surgical procedures performed because of such lesions.RESULTS: There were 134 ASCUS cases included. Overall, there were 48 (35.8%) surgical excision procedures performed to treat or eliminate HGSIL during the follow-up period. According to the final histopathology of surgical specimens, the cumulative rate of CIN2 or higher cervical lesions was 28.4% (n = 38).CONCLUSION: The cumulative rate of CIN2+ during follow-up period was almost 30% for patients with ASCUS, with the necessity for interventional treatment being even higher. |
DOI | 10.1159/000448138 |
Alternate Journal | Gynecol. Obstet. Invest. |
PubMed ID | 27618466 |