The effect of leptin replacement on parathyroid hormone, RANKL-osteoprotegerin axis, and Wnt inhibitors in young women with hypothalamic amenorrhea.
Τίτλος | The effect of leptin replacement on parathyroid hormone, RANKL-osteoprotegerin axis, and Wnt inhibitors in young women with hypothalamic amenorrhea. |
Publication Type | Journal Article |
Year of Publication | 2014 |
Authors | Foo, J-P., Polyzos S. A., Anastasilakis A. D., Chou S., & Mantzoros C. S. |
Journal | J Clin Endocrinol Metab |
Volume | 99 |
Issue | 11 |
Pagination | E2252-8 |
Date Published | 2014 Nov |
ISSN | 1945-7197 |
Λέξεις κλειδιά | Adolescent, Adult, Amenorrhea, Bone Morphogenetic Proteins, Double-Blind Method, Female, Fibroblast Growth Factors, Genetic Markers, Hormone Replacement Therapy, Humans, Hypothalamic Diseases, Intercellular Signaling Peptides and Proteins, Leptin, Osteoprotegerin, Parathyroid Hormone, RANK Ligand, Treatment Outcome, Young Adult |
Abstract | CONTEXT: Recombinant leptin (metreleptin) treatment restores bone mineral density in women with hypothalamic amenorrhea (HA), a condition characterized by hypoleptinemia, which has adverse impact on bone health. |
DOI | 10.1210/jc.2014-2491 |
Alternate Journal | J. Clin. Endocrinol. Metab. |
PubMed ID | 25148234 |
PubMed Central ID | PMC5393498 |
Grant List | M01 RR001032 / RR / NCRR NIH HHS / United States M01-RR-01032 / RR / NCRR NIH HHS / United States |