Histopathological study of perilesional skin in patients diagnosed with nonmelanoma skin cancer.
Τίτλος | Histopathological study of perilesional skin in patients diagnosed with nonmelanoma skin cancer. |
Publication Type | Journal Article |
Year of Publication | 2016 |
Authors | Apalla, Z., Calzavara-Pinton P., Lallas A., Argenziano G., Kyrgidis A., Crotti S., Facchetti F., Monari P., & Gualdi G. |
Journal | Clin Exp Dermatol |
Volume | 41 |
Issue | 1 |
Pagination | 21-5 |
Date Published | 2016 Jan |
ISSN | 1365-2230 |
Λέξεις κλειδιά | Adolescent, Adult, Aged, Aged, 80 and over, Bowen's Disease, Carcinogenesis, Carcinoma, Basal Cell, Carcinoma, Squamous Cell, Female, Humans, Male, Middle Aged, Prospective Studies, Risk Factors, Skin, Skin Neoplasms, Ultraviolet Rays, Young Adult |
Abstract | BACKGROUND: Epidemiological and clinical data suggest that actinic damage to the skin is an important predictor of skin carcinogenesis.AIM: To investigate the association of squamous cell carcinoma (SCC) and basal cell carcinoma (BCC) with sun-damage alterations seen by histopathology.METHOD: In the current prospective study, perilesional skin of SCC or BCC lesions was evaluated for presence of alterations associated with chronic photodamage. Presence of scarring, perineural/perivascular invasion, haemorrhage/haemorrhagic crust, ulceration/erosion and margin involvement were also assessed.RESULT: Of 6038 included lesions, 4523 (74.9%) were BCCs and 1515 (25.1%) were SCCs. Presence of actinic damage was five times more frequent in SCC than in BCC (OR = 5.29, 95% CI 4.44-6.00, P < 0.001), and diagnosis of SCC was twice as common in photo-exposed than nonphoto-exposed body sites (OR = 2.34, 95% CI 2.03-2.70, P < 0.001). There were twofold higher odds for actinic damage in SCC compared with Bowen disease (OR = 2.015, 95% CI 1.55-2.61, P < 0.001). Assessing the different BCC histological subtypes, we found that nodular BCC had at least twofold higher odds (OR = 2.63, 95% CI 2.09-3.32), infiltrative BCC had 48% higher odds (OR = 1.487, 95% CI 1.18-1.87) and basosquamous BCC had fourfold higher odds (OR = 4.10, 95% CI 3.01-5.57) of having actinic damage compared with superficial BCC.CONCLUSIONS: Histological verification of ultraviolet-associated alterations in the perilesional skin in patients with NMSC in our study confirms the aetiopathogenic link between sun exposure and epithelial carcinogenesis on a histopathological basis. This correlation was stronger for SCCs than for BCCs. |
DOI | 10.1111/ced.12713 |
Alternate Journal | Clin Exp Dermatol |
PubMed ID | 26189480 |