Low-grade chondrosarcomas: a difficult target for radionuclide imaging. Case report and review of the literature.
Τίτλος | Low-grade chondrosarcomas: a difficult target for radionuclide imaging. Case report and review of the literature. |
Publication Type | Journal Article |
Year of Publication | 2002 |
Authors | Arsos, G., Venizelos I., Karatzas N., Koukoulidis A., & Karakatsanis C. |
Journal | Eur J Radiol |
Volume | 43 |
Issue | 1 |
Pagination | 66-72 |
Date Published | 2002 Jul |
ISSN | 0720-048X |
Λέξεις κλειδιά | Aged, Bone Neoplasms, Chondrosarcoma, Female, Femoral Neoplasms, Fluorodeoxyglucose F18, Humans, Organophosphorus Compounds, Organotechnetium Compounds, Radionuclide Imaging, Radiopharmaceuticals, Technetium Tc 99m Sestamibi, Thallium Radioisotopes |
Abstract | Bone scan with Tc-99m (technetium) diphosphonate is sensitive, but non-specific for musculoskeletal tumors. Tl-201 (thallium), Tc-99m-sestamibi, Tc-99m-tetrofosmin, and F-18-fluorodeoxyglucose (F-18-FDG) can visualize tumors more specifically and are therefore useful in orthopedic oncology. However, cartilaginous tumors are characterized by histological and biological features, which potentially impair specific radionuclide imaging. A case of a patient with a low-grade primary chondrosarcoma of the femur and a false negative Tl-201 scan is presented. Tc-99m-based tumor-localizing compounds (sestamibi, tetrofosmin), as well as metabolic and receptor-imaging radiopharmaceuticals have also been reported to fail in low-grade chondrosarcomas imaging. Low cellularity, mitochondrial specialization and the presence of an efflux membrane pump may contribute to poor imaging. A negative Tl-201 or Tc-99m-sestamibi scan should be interpreted with caution, when the possibility of a chondrosarcoma is not negligible. |
DOI | 10.1016/s0720-048x(01)00427-2 |
Alternate Journal | Eur J Radiol |
PubMed ID | 12065124 |