Pro-brain natriuretic peptide is a sensitive marker for detecting cardiac metastases in patients with non-small cell lung cancer.
Τίτλος | Pro-brain natriuretic peptide is a sensitive marker for detecting cardiac metastases in patients with non-small cell lung cancer. |
Publication Type | Journal Article |
Year of Publication | 2009 |
Authors | Lafaras, C., Mandala E., Saratzis A., Platogiannis D., Barbetakis N., Papoti S., Christopoulou M., Ilonidis G., & Bischiniotis T. |
Journal | Onkologie |
Volume | 32 |
Issue | 7 |
Pagination | 389-92 |
Date Published | 2009 Jul |
ISSN | 1423-0240 |
Λέξεις κλειδιά | Aged, Aged, 80 and over, Carcinoma, Non-Small-Cell Lung, Female, Heart Neoplasms, Humans, Lung Neoplasms, Male, Middle Aged, Natriuretic Peptide, Brain, Peptide Fragments, Reproducibility of Results, Sensitivity and Specificity, Tumor Markers, Biological |
Abstract | BACKGROUND: B-type natriuretic peptide (BNP) and N-terminal-pro-BNP (NT-pro-BNP) are important diagnostic tools for patients with suspected cardiac disorders. The aim of this study was to evaluate the predictive value of plasma NT-pro-BNP in identifying cardiac metastases in patients with non-small cell lung cancer (NSCLC) and dyspnoea.PATIENTS AND METHODS: A total of 120 patients, median age 62 years (range 46-83), with NSCLC and dyspnoea were studied. Patients with heart failure or documented coronary artery disease were excluded. Echocardiographic imaging was used to detect cardiac metastases and estimate global left ventricular function. Ejection fraction and E/A ratio from transmitral inflow pattern were calculated. Plasma NT-pro-BNP was also measured. 72 patients (72/120, 60%) with cardiac metastases were identified.RESULTS: NT-pro-BNP was significantly higher in patients with metastases (1347.5 +/- 1004.30 pg/ml vs. 159.02 +/- 93.29 pg/ml; p = 0.001). No differences between groups, regarding s-creatinine (p = 0.45), haemoglobin (p = 0.71), left ventricular hypertrophy (p = 0.91), and diastolic dysfunction (p = 0.79), were observed.CONCLUSION: Plasma NT-pro-BNP is remarkably elevated in patients with NSCLC and myocardial/pericardial infiltrations and may be used as a sensitive marker for detecting cardiac metastases in these patients. |
DOI | 10.1159/000218368 |
Alternate Journal | Onkologie |
PubMed ID | 19556815 |