Role of electroretinography in the assessment of retinal function as an indicator of vitamin A status.
Τίτλος | Role of electroretinography in the assessment of retinal function as an indicator of vitamin A status. |
Publication Type | Journal Article |
Year of Publication | 2000 |
Authors | Tsinopoulos, I., Nousia-Arvanitakis S., Galli-Tsinopoulou A., Roubies N., Tentzidou K., Xefteri M., & Stangos N. |
Journal | Doc Ophthalmol |
Volume | 101 |
Issue | 3 |
Pagination | 211-21 |
Date Published | 2000 Nov |
ISSN | 0012-4486 |
Λέξεις κλειδιά | Adolescent, Adult, Child, Cystic Fibrosis, Dietary Supplements, Electroretinography, Female, Humans, Male, Retina, Vitamin A, Vitamin A Deficiency, Zinc |
Abstract | Hypovitaminosis A is associated with exocrine pancreatic insufficiency in cystic fibrosis. Peripheral retinal dysfunction is an early finding of vitamin A deficiency. We evaluated serum retinol and zinc as well as visual adaptation in 41 patients with cystic fibrosis, receiving generous pancreatic enzyme and micronutrient supplementation. Forty-one normal individuals matched for age and sex served as controls. Peripheral retinal function was measured by clinical electroretinography using an Electrophysiologic Personal Interfaced Computer and applying a standard protocol. Serum retinol in cystic fibrosis was significantly lower than that of the control group (0.30+/-0.01 versus 0.39+/-0.02 mg/l, p<0.001). Serum zinc concentrations were normal in the cystic fibrosis group (1.21+/-0.03 mg/l) and significantly higher than that of the control group (1.02+/-0.01 mg/l, p<0.001). The overall visual adaptation, however, was found to be normal and comparable in the two groups. It is concluded that, in cystic fibrosis, despite appropriate vitamin A supplementation, retinol serum concentration may be low. As serum retinol does not reflect vitamin A status, evaluation of visual adaptation may be a more appropriate way to monitor for vitamin A deficiency in cystic fibrosis. |
DOI | 10.1023/a:1002793728087 |
Alternate Journal | Doc Ophthalmol |
PubMed ID | 11291950 |